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Non-systemic TGR-5 agonist


Non-systemic TGR5 agonist program for T2D and Metabolic Syndrome. TGR-5 receptors play a key role mediating secretion of glucagonlike peptide 1 (GLP-1) by enteroendocrine L-cells which results in increase of insulin secretion normalizing blood glucose excursions and other critical biochemical and metabolic abnormalities leading to therapeutic effect in patients with T2D.